In the present study, we investigated the changes in bone resorption, gingival TNF-α (pro-inflammatory marker) mRNA levels, and gingival soluble RANKL protein levels in ligation-induced experimental peri-implantitis in WT and TLR2/4 KO mice with or without anti-RANKL antibody alone treatment and anti-RANKL antibody + miR-146a treatment. This evidence concerns the gene TLR2 and Peri-Implantitis.