In the present study, the data showed that miR-146a have no effects on inflammatory cell infiltration or TNF-α expression in the absence of TLR2 and TLR4 in experimental peri-implantitis, suggesting that miR-146a anti-inflammation effects are TLR2/4 dependent in peri-implantitis. The gene discussed is TLR4; the disease is Peri-Implantitis.