Taken together, miR-146a in addition to anti-RANKL antibody can further reduce bone loss in WT mice but is ineffective when TLR2 and TLR4 are deficient, suggesting miR-146a anti-bone loss effects in peri-implantitis are TLR2/4 dependent. The gene discussed is TNFSF11; the disease is Peri-Implantitis.