A preclinical animal study has shown that inhibiting glutamine metabolism using the glutaminase inhibitor CB-839 leads to impaired redox homoeostasis and sensitises IDH-mutated glioma to radiotherapy.25 In our studies,51,55,92 we have shown that suppression of Nrf2 by the natural compound brusatol resulted in profound tumour suppression in IDH1-mutated xenografts, along with overwhelming oxidative damage. This evidence concerns the gene IDH2 and central nervous system cancer.