In the case of exogenous nucleation of WH1(WT) amyloids by WH1(A31V) fibers, proteins annotated as involved in neurodegenerative diseases were identified (Crat, Hexb, Pld3, and Sel1l), while other proteins were annotated as related to ubiquitin ligases and proteasome-mediated degradation pathways (Fbxo2 and Isg15). This evidence concerns the gene FBXO2 and neurodegenerative disease.