This study aimed to investigate the linkage between serum markers of obesity and risk of cardiovascular diseases, with particular reference to the adipokines galectin-3, plasminogen activator inhibitor-1 (PAI-1), IL-1β, CRP, monocyte chemoattractant protein-1 (MCP-1), and insulin. This evidence concerns the gene SERPINE1 and obesity due to melanocortin 4 receptor deficiency.