As Runx2 is involved in the pathogenesis of osteoarthritis and the inflammatory processes induced by mechanical injury lead to the development of post-traumatic osteoarthritis [30,31,32,33], Hck may also be involved in the development of osteoarthritis, especially in osteophyte formation because of the capacity to promote chondrocyte proliferation. The gene discussed is RUNX2; the disease is osteoarthritis.