The fact that mutations in ADAMTS10, ADAMTS17, fibrillin-1 (FBN1), LTBP2, or LTBP3 can cause almost identical short stature syndromes, called acromelic dysplasias, further supports the concept that some ADAMTS proteases in this central clade, specifically ADAMTS10 and ADAMTS17, are functionally connected through their ECM substrates [14,16,17,18]. The gene discussed is FBN1; the disease is acromelic dysplasia.