ITPR3 and Graves disease: In the same study, ITPR was also associated with type 1 diabetes mellitus [86], reflecting the similarity of genetic perturbations and the comparable immunological dysfunctions underlying these diseases, further corroborated by genetic analyses identifying ITPR3 as an independent risk locus in Graves’ disease [87] and allergic disorders including asthma, allergic rhinitis, atopic dermatitis [88,89], and airflow obstruction [90].