ITPR1 and familial dilated cardiomyopathy: The association between gene expression and dilated cardiomyopathy (DCM) has been studied by assessing the presence of CpG sites in the proximity of gene-promoters, as an index of promoter methylation and consequent downregulation of transcription [101]; using this strategy, the CpG site “cg26395694” close to the ITPR1 locus (ENSG00000150995) has been shown to be significantly associated to DCM (p-value: 2.57E-02).