Quercetin and EGCG worked synergistically and exerted inhibitory effects on cytokine-mediated upregulation of iNOS (inducible nitric oxide synthase) and ICAM-1 (intercellular adhesion molecule-1) via JAK/STAT cascade in cholangiocarcinoma cells (Figure 1) [12]. Here, NOS2 is linked to cholangiocarcinoma.