Diabetes was reported to upregulate the expression of hepatic Mdr1b (ABCB1b) mRNA and P-gp protein in 8-day diabetic Wistar rats (type 1 diabetes) induced by STZ, which was associated with the activation of protein kinase C alpha (PKCα) and nuclear factor kappa-B (NF-κB) [16]. This evidence concerns the gene PGP and diabetes mellitus.