TNF and colitis: The inhibitory effects observed for this molecule (compound 2, also 11-hydroxy-1′-O-methylamentadione or AMT-E) on THP-1 cells are consistent with the in vivo study described in our previous report, which showed exerting intestinal anti-inflammatory activity in colitis by down-regulating TNF-α, IL-1ß, and IL-10, as well as suppressing COX-2 and iNOS expression in the mouse colon tissue [46].