SRC and osteosarcoma: Indeed, low aggressive osteosarcoma SaOS-2 cells show high content of nuclear Src with a low myristoylation and low expression of N-myristoyltransferase (NMT) enzymes, in comparison to high metastatic 143B osteosarcoma cells, in which nuclear Src is lower while myristoylation and NMT expression is very high [46].