HDAC5 and cancer: Methionine restriction, which affects DNA methyltransferase (DNMT) activity, results in a rapid accumulation of APBs [50], whereas depletion of anti-silencing function 1a/1b histone chaperones, which coordinate the shuttling of histone proteins during DNA replication, or of histone deacetylase 5 (HDAC5), results in ALT induction (i.e., APB formation or telomere recombination) in telomerase-positive cancer cell lines [51,52].