Compared to IMR90, a fibroblast and PHATE_1-high cell type, we observed dramatic increase in the post-translationally modified (activated/ mono-ubiquitinated) forms of FANCD2 and FANCI protein in Ewing sarcoma cells (black triangles, Figure 7A) and a marked increase in cell death with knockdown of multiple Fanconi anemia genes (Figure 7B). Here, FANCD2 is linked to Ewing sarcoma.