Ewing sarcoma is an aggressive cancer of the bone and soft tissues resulting from the fusion of Ewing sarcoma RNA Binding Protein 1 (EWSR1) to Friend leukemia integration 1 transcription factor (FLI1) (85%) or E-twenty-six-related (ETS-related) gene (ERG) (15%) [1]. The gene discussed is EWSR1; the disease is Ewing sarcoma.