Indeed, matriptase expression is reported to be upregulated in various cancers (breast, ovarian, uterine, colon, cervical, skin, pancreatic, esophageal, head and neck, prostate, bladder and renal cell carcinoma: RCC) with poor prognosis [3,10,11,12,22]. The gene discussed is ST14; the disease is hereditary clear cell renal cell carcinoma.