The protection against the development of liver cancer in carcinogen-treated mice also depends on ERα-mediated estrogen signaling of forkhead box protein A (Foxa) factors such as Foxa1 and Foxa2 [101] pioneer transcription factors in the liver, crucial for steroid hormone signalling (estrogens and androgens) as essential controllers of variations of liver cancer in terms of gender [95]. The gene discussed is FOXA2; the disease is liver cancer.