It was also shown that decreased expression of ERα mRNA due to inhibition of ion channel (KCNN4; Ca2+-activated K+ channel) by TRAM-34 (1-[(2-chlorophenyl)diphenylmethyl]-pyrazole) led to a decrease in activation of NF-kappaB, the factor known to be involved in the development of HCC [130]. Here, ESR1 is linked to hepatocellular carcinoma.