ERBB2 and breast cancer: Additionally, both in vitro and in vivo models have recently described the role of PRDM1/Blimp1 in p130Cas/ErbB2 breast cancer invasion; particularly, Blimp1 was highly expressed during p130Cas/ErbB2 dependent invasion in breast cancer cells and the downregulation of its expression was sufficient to severely impair tumor invasiveness in vitro and lung metastasis formation in vivo [39].