PRDM14 and leukemia: Interestingly, through the use of mice transduced with bone marrow cells carrying a Prdm14-expressing vector and microarray analysis, it was demonstrated that this gene is able to initiate leukemia due to expansion of a cell population with features of common lymphoid progenitors, which expressed high levels of genes involved in pluripotency, tumor initiation, early B-lineage commitment, the oncogenic Wnt/Ras signaling pathways, and EMT [191].