PRDM14 and cancer: Furthermore, the effects of PRDM14 specific siRNAs were also investigated in vivo on the growth of tumor xenografts and metastasis with successful results and no adverse effects; these beneficial effects were also confirmed in a conditional Prdm14 knockout MMTV-Wnt-1 transgenic mice, a spontaneous murine model of breast cancer suggesting that PRDM14 inhibition may be an effective and novel therapy targeting cancer stem cells (Figure 5) [186,187].