Hence, in this indirect comparison, we compared, for the first time—using PFS as an efficacy endpoint—brigatinib, alectinib, and crizotinib, with the recommended or approved dosages and modes of administration for advanced NSCLC patients and showed that alectinib ranked the highest for the overall patient population with ALK-p NSCLC, whereas brigatinib ranked the highest for ALK-p NSCLC with CNS metastasis patients. This evidence concerns the gene ALK and non-small cell lung carcinoma.