ALK and non-small cell lung carcinoma: However, there are no reports of any large-scale, head-to-head, randomized, controlled trials (RCT) in ALK-inhibitor-naïve NSCLC patients with CNS metastasis that compare currently the recommended dosages and administration frequency of ALK inhibitors or brigatinib with those of alectinib, which is currently positioned as a first-line treatment.