Although anti-VEGF drugs are the main pharmacological approach for macular edema and neovascularization in DR and retinal vein occlusion, and for exudative age-related macular degeneration, long-term VEGF antagonism may induce photoreceptor and Retinal pigment epithelium (RPE) cell atrophy [10,11]. The gene discussed is VEGFA; the disease is age-related macular degeneration.