Compared to the AKI + IA animals, treatment with IA EVs significantly decreased urine KIM-1 (21.8 ± 3.1 vs. 1.6 ± 1.1 mg/dL, p < 0.05), decreased urine NGAL though not reaching statistical significance (20.0 ± 2.8 vs. 13.7 ± 4.5 mg/dL, p > 0.05), and had no effect on urine TIMP-1 (4.7 ± 1.7 vs. 6.1 ± 0.9 mg/dL, p > 0.05). The gene discussed is TIMP1; the disease is acute kidney injury.