Compared to untreated controls, serum levels of proinflammatory cytokines were significantly upregulated in the AKI + IA saline group, including TNF-α (469.2 ± 68.8 vs. 1597.4 ± 291.4 pg/mL, p < 0.05), and IL-6 (414.9 ± 35.1 vs. 1345.1 ± 244.2 pg/mL, p < 0.05) (Figure 3B). The gene discussed is TNF; the disease is acute kidney injury.