Compared to the AKI + IA saline group, those treated with IA EVs had significant downregulation of both TNF-α (1597.4 ± 291.4 vs. 698.7 ± 125.3 pg/mL, p < 0.05) and IL-6 (1345.1 ± 244.2 vs. 694.5 ± 244.2 pg/mL, p < 0.05). This evidence concerns the gene IL6 and acute kidney injury.