Compared to untreated controls, those in the AKI + IA saline group had significant downregulation of both pAMPK (3.4 ± 0.4 vs. 0.3 ± 0.1 relative expression, p < 0.05) and pERK (2.9 ± 0.2 vs. 1.3 ± 0.2 relative expression, p < 0.05) (Figure 4C). Here, EIF2AK3 is linked to acute kidney injury.