In addition, there are several overexpressed HA binding receptors in cancer cells compared to normal cells, such as cluster of differentiation 44 (CD44) [12,13,14], lymphatic vessel endocytic receptor (LYVE-1) [15], and the receptor for hyaluronic acid-mediated motility (RHAMM) [16] (Figure 1b). The gene discussed is CD44; the disease is cancer.