In this study, our aim was to determine whether S100A4, one of the most important biomarkers for invasiveness, previously identified in a list of 137 proteins [17], was involved in all stages of MM pathogenesis, including tumorigenesis, EMT, invasion, and colonization of host organs, and whether it presented a comparable evolution during the whole process when used alone or when combined with other proteins of interest. Here, S100A4 is linked to Miyoshi myopathy.