To summarize, in line with previous observations that in normal and benign lesions, S100A4 is restricted to a few stromal fibroblasts and inflammatory cells [42], while both tumor and stromal cells secrete the protein in malignant tumors [42,43], we observed a continuous rise in S100A4 from subnormal, epithelioid, sarcomatoid non-tumorigenic mesothelial cells to MM cell lines. This evidence concerns the gene S100A4 and Miyoshi myopathy.