WNK2 and malignant colon neoplasm: Other than S100A4, our study also led us to identify several other potential markers of interest for MM, including annexin A5 [60], as its serum level in patients with colon cancer is related to lymph node metastasis and tumor grades [61], while investigations of its role and action in hepatocarcinoma malignancy has revealed that its knockdown suppressed the expression of key molecules in the integrin and MEK-ERK pathways (mitogen-activated protein kinases-extracellular signal-regulated kinases) [62].