Given the synergistic effect of CTX, but not of CDDP, pre-treatment on anti-PDL therapy and the absence of tumor-specific CD8+ T cells in mice implanted with MCA205-Tlr-3-/- treated with CTX + anti-PDL1/2 Ab, we hypothesized that the induction of ICD by CTX could be the key mechanisms underlying the synergisms between chemotherapy and PDL blockade. This evidence concerns the gene CD8A and neoplasm.