From the analysis of the phenotype and function of tumor-infiltrating lymphocytes (TILs), we observed that the frequency of CD4+ and CD8+ T cells in the two treatment groups was similar (Figure 1E), while anti-PDL treatment was associated with higher frequencies of CD8+ T cells with an effector-memory phenotype (CD44hiCD62L-, Figure 1F). This evidence concerns the gene CD4 and neoplasm.