Kanwar et al., in a DSS model of colitis, used oral delivery of bovine milk-derived iron-saturated lactoferrin (Fe-Blf), angiogenin, osteopontin colostrum whey protein, Modulen IBD, cis-9, trans-11 conjugated linoleic acid (CLA)-enriched milk fat and showed that each milk component attenuated experimental colitis but with a different effectiveness against specific disease parameters. This evidence concerns the gene SPP1 and colitis.