Importantly, the US Food and Drug Administration (FDA) and European Medicines Agency (EMA) in 2015 have approved T-VEC (Imlygic), an oncolytic herpes virus lacking ribonucleotide reductase and also expressing granulocyte-macrophage colony-stimulating factor (GM-CSF), for the treatment of locally advanced or non-resectable melanoma, opening the way for new therapeutic protocols [90]. This evidence concerns the gene CSF2 and melanoma.