Figure 5 shows that the highest mortality rate in both WT and VDAC1 KO mice occurred within 48 h after ischemia. The animal loss within this critical period was 24% in WT and 50% in VDAC1 KO mice. On the seventh day after ischemia, mortality rate was 37% and 61% in WT and VDAC1 KO mice, respectively (Figure 5). No animals were lost from the sham-operated group. These results show that the deletion of VDAC1 increases (by 65%) mortality due to AKI and suggest that functional VDAC1 plays a critical role in survival after AKI (Figure 5). Here, VDAC1 is linked to acute kidney injury.