A CRISPR-based in vitro and in vivo screen to identify mechanisms allowing tumor escape from CD8+ T cells and natural killer cells showed that the deletion of Casp8, Tnfrsf1a and Ado within the TNF-signaling pathway, or Ifngr1/2, Jak1/2 and Stat1 in the IFN-γ-signaling pathway, protected tumor cells against CD8+ T cell and/or NK cell-mediated killing and blunted the efficacy of anti-tumor responses in vivo [102]. Here, CASP8 is linked to neoplasm.