DPP4 and type 2 diabetes mellitus: In another observational study, including 59 patients with T2D, the oral fixed-dose combination of the SGLT2i dapagliflozin and dipeptidyl peptidase-4 inhibitor (DPP4i) saxagliptin significantly decreased liver fat and adipose tissue volume versus glimepiride, and reduced serum liver enzyme levels, indicating a favorable metabolic profile of this combination in patients with T2D on metformin therapy [236].