For instance, a recent animal study showed that Sirt3 deficiency exacerbated diabetic cardiomyopathy, while Sirt3 overexpression promoted mitochondrial homeostasis and cardiomyocyte survival through induction of mitophagy and autophagy via Sirt3-Foxo3A-Parkin signaling [57]. This evidence concerns the gene FOXO3 and diabetic cardiomyopathy.