Moreover, through its association with CK1α, PAWS1 can activate the Wnt signaling pathway [5] and mutations in PAWS1 that are implicated in palmoplantar keratoderma, lose interaction with CK1α and consequently have attenuated Wnt signaling [7]. Here, CSNK1A1 is linked to epidermolytic palmoplantar keratoderma, 1.