CHI3L1 and Cowden disease: Several serum factors (miR-19, miR29, collagen, fibronectin, tissue inhibitor of matrix metalloproteinase-1, basic fibroblasts growth factor, chitinase 3-like 1 (YKL-40), anti-Saccharomyces cerevisiae antibodies, and fibrocytes) had shown conflicting results with low specificity for stricturing CD patients [8].