Data from the Catalogue of Somatic Mutation in Cancer (COSMIC) v89 [82] indicated that amongst hundreds of HCC samples tested, 0.33% (3/899) had point mutations in the ACSL4 gene, 0.73% (5/682) had copy number variations and 11.8% (44/373) had upregulated gene expression. This evidence concerns the gene ACSL4 and hepatocellular carcinoma.