The performance of ACSL3 expression for distinguishing HCC from both normal tissue (area under the curve (AUC) 0.796; CI (0.669 – 0.923); sensitivity 85.8 %; specificity 75.0 %) and CCA (AUC 0.803; CI (0.624–0.963); sensitivity 87.2; specificity 75.0 %) was good (Table 3). The gene discussed is ACSL3; the disease is hepatocellular carcinoma.