In this study, we have analyzed the hybrid capture NGS gene panel data of eight genetically unresolved CCM index patients for the presence of SVs in CCM1, CCM2 or CCM3. An interchromosomal insertion which led to an interruption of exon 6 of the CCM2 gene was identified in a sporadic CCM patient. The gene discussed is KRIT1; the disease is cerebral cavernous malformation.