To further examine the underlying molecular mechanisms, we performed microarray analysis on HCASMCs treated with or without TNF-α and found a significant overlap between cancer-related genes and cardiovascular disease-related genes including Cyclin A2, Cyclin D1, c-Myc, and PCNA, which were all significantly induced but negated by RSV treatment (Supplementary Fig. S6). The gene discussed is CCNA2; the disease is cardiovascular disorder.