Several studies concerning changes in aqueous cytokine profiles in different clinical entities of uveitis, including infectious uveitis29, Bechet’s disease, Vogt-Koyanagi-Harada disease30,31, Fuchs heterochromic cyclitis, and other clinically idiopathic uveitis32–37 have reported that increased levels of IL-6, CCL (C-C motif ligand) 2, and CXC Chemokine Ligand (CXCL) 8 are the most commonly observed changes associated with ocular inflammatory disease in general, and similar changes in these cytokines were also reported in PSS patients26. This evidence concerns the gene IL6 and peeling skin syndrome.