A more recent paper reported that short-term cooling can elevate the levels of ANGPTL3, 4 and 8 in the plasma of young healthy lean men; however, in middle-aged men who were overweight and had prediabetes, only the levels of ANGPTL4 were increased with no effect on the levels of ANGPTL3 and 844. Here, ANGPTL4 is linked to prediabetes syndrome.