Based on this result, we selected 10 genes (PLAU, SFTPA2, CCL26, SEMA3G, DKK1, GAST, GNRH1, PDGFA, ZAP70, and STC1) and 11 genes (SEMA3G, GNRH1, TNFRSF4, ZAP70, PLAU, SH2D1A, CCL26, DKK1, GAST, PDGFA and STC1) that were closely related to clinical prognosis to construct two prognostic prediction models to assess potential clinical outcomes for the total HNSCC patients and HPV- HNSCC patients. This evidence concerns the gene SH2D1A and head and neck squamous cell carcinoma.