Based on this result, we selected 10 genes (PLAU, SFTPA2, CCL26, SEMA3G, DKK1, GAST, GNRH1, PDGFA, ZAP70, and STC1) and 11 genes (SEMA3G, GNRH1, TNFRSF4, ZAP70, PLAU, SH2D1A, CCL26, DKK1, GAST, PDGFA and STC1) that were closely related to clinical prognosis to construct two prognostic prediction models to assess potential clinical outcomes for the total HNSCC patients and HPV- HNSCC patients. The gene discussed is PDGFA; the disease is head and neck squamous cell carcinoma.