Moreover, as shown in Fig. 4j and k and Supplementary Fig. 2b, CXCR3+CD8+ T cells (in the non-irradiated tumor) and CXCL9 (in the serum) were decreased in FTY720 treated, irradiated β2-AR KO mice compared to controls, suggesting that CXCR3/CXCL9 may play an important role in CD8+ T cell migration to tumors in the absence of β2-AR expression. The gene discussed is CXCL9; the disease is neoplasm.