PDCD1 and neoplasm: Comparison of tumor growth (Supplementary Fig. 7b) showed that compared to PBS, Prop significantly enhanced the tumor control of irradiated and non-irradiated tumors in the mice treated with anti-PD-1 antibody, suggesting that adrenergic stress interferes with the effects of the combination of radiotherapy and immunotherapy, which can be overcome by the treatment of β-blocker.