We also checked chemokine receptor C-X-C chemokine receptor type 3 (CXCR3) on CD8+ T cells in distant non-irradiated tumor and its ligand C-X-C motif chemokine 9 (CXCL9) in serum, which are associated with CD8+ T cell egress42–44, and found that both CXCR3 and CXCL9 increased in irradiated β2-AR KO mice compared to irradiated WT mice (Fig. 3g and h), supporting the possibility that absence of β2-AR signaling enhances the migration of CD8+ T cells by CXCR3/CXCL9 interactions. Here, CXCR3 is linked to neoplasm.