Here, we provide raw FASTQ and bigwigs for a comprehensive, validated ChIP-Seq (MYCN, MYC, H3K27Ac, H3K27me3, H3K4me3, and H3K4me1) and ATAC-Seq neuroblastoma cell line dataset which can be coupled with our previous RNA-Seq profiling dataset16 to interrogate novel transcriptional regulation in this disease. This evidence concerns the gene MYC and neuroblastoma.