KIF5B and neoplasm: Indeed, a lack of Kif5b dramatically impaired (i) IL-2 secretion from OT-I T cells upon cross-presentation of sOVA or particulate OVA by DCs, (ii) an in vivo anti-tumour response, (iii) the degradation of soluble or particular Ags, (iv) acidification and proteolysis activity of the endocytic pathway, (v) sOVA intracellular trafficking, (vi) MHC-I recycling and (vii) early endosome dynamics, including the scission of tubulations from early endosomes (Supplementary Fig. 13).