CD274 and melanoma: Consistent with the ICB treatment data sets, we observed significantly higher TMB (linear regression model, p = 0.038; Benjamini and Hochberg correction, FDR = 0.17; Supplementary Fig. 6a; The same statistical analysis for p and FDR was performed in this section), single nucleotide variation neoantigen load (p = 0.0072; FDR = 0.12; Supplementary Fig. 6b) and PD-L1 (p = 0.0036; FDR = 0.035; Supplementary Fig. 6c) in male patients with melanoma (Fig. 3b).