In contrast, we observed a female-biased pattern for patients with lung cancer in TCGA based on immune checkpoints (e.g., BTLA and CD80) and immune cell populations (e.g., activated CD4+/CD8+ T cell) and validated this pattern in one independent data set (GSE47115)32 (Supplementary Fig. 7b). The gene discussed is CD80; the disease is lung carcinoma.