These include cell-surface markers (IL12RB2, IL23R, and CD26) and the transcription factor RORC. In contrast, the Vδ1 lymphomas had elevated expression of transcripts that were also elevated in untransformed, circulating Vδ1 cells, including the transcription factor LEF1 and the cell-surface receptor TIGIT. Consistent with their localization to the epidermis and dermis, Vδ1 lymphomas expressed significantly increased levels of CCR8 compared to Vδ2 lymphomas, a chemokine receptor normally found on untransformed epidermis and dermis-resident memory T cells20. Here, TIGIT is linked to lymphoma.