Indeed, a PUFA-enriched WD containing 10% fish oil (with ω-3 and ω-6 PUFAs) evoked focal neutrophilic enteritis in male and female Gpx4+/−IEC mice that was characterized by granuloma-like mucosal to submucosal accumulation of inflammatory cells and expression of the IL-8 homologue Cxcl1. As such, our findings represent first evidence that non-toxic dietary lipids trigger focal enteritis in a genetically susceptible host resembling some aspects of human small intestinal CD. Here, CXCL1 is linked to enteritis.