Blocking glycogen metabolism by either GPI or 6AN effectively inhibited sepsis, as evidenced by (1) 80% mice were rescued from septic death (Fig. 7f); (2) CLP-induced organic damage (liver, kidney and heart) was relieved (Fig. 7g, h); and (3) the levels of released inflammatory cytokines such as TNF and IL-6 were reduced (Fig. 7i). Here, TNF is linked to Sepsis.