To test whether ROS or RNI contributed to genetic damage, IL10−/− mice infected with H. typhlonius and H. mastomyrinus were given the iNOS inhibitor L-N6-(1-Iminoethyl) lysine dihydrochloride (L-NIL) or the antioxidant NAC in their drinking water for 8 weeks post infection. This evidence concerns the gene NOS2 and infection.