In fact, variants at numerous other genetic loci related to endocytic trafficking and synaptic maintenance have been discovered as risk factors for Alzheimer’s disease (BIN1, PICALM, CD2AP, SORL1) (Karch et al., 2014) and Parkinson’s disease (SNCA, LRRK2, SH3GL2/EndoA, RAB7L1) (Soukup et al., 2018). This evidence concerns the gene SORL1 and Alzheimer disease.