PICALM and early-onset autosomal dominant Alzheimer disease: In fact, variants at numerous other genetic loci related to endocytic trafficking and synaptic maintenance have been discovered as risk factors for Alzheimer’s disease (BIN1, PICALM, CD2AP, SORL1) (Karch et al., 2014) and Parkinson’s disease (SNCA, LRRK2, SH3GL2/EndoA, RAB7L1) (Soukup et al., 2018).