Mutations in VPS35—encoding a retromer core protein—are a rare cause of familial Parkinson’s disease (Vilariño-Güell et al., 2011; Zimprich et al., 2011), and retromer has also been linked to endocytic trafficking and processing of the Amyloid Precursor Protein and Tau in Alzheimer’s disease (Muhammad et al., 2008; Vagnozzi et al., 2019; Wen et al., 2011). The gene discussed is VPS35; the disease is Alzheimer disease.