In fact, variants at numerous other genetic loci related to endocytic trafficking and synaptic maintenance have been discovered as risk factors for Alzheimer’s disease (BIN1, PICALM, CD2AP, SORL1) (Karch et al., 2014) and Parkinson’s disease (SNCA, LRRK2, SH3GL2/EndoA, RAB7L1) (Soukup et al., 2018). The gene discussed is SNCA; the disease is early-onset autosomal dominant Alzheimer disease.