Western blot analysis showed that USP44 overexpression increased Axin1 protein while decreasing β‐catenin, c‐myc and Cyclin D1 proteins in both CRC cell lines (Figure 4), suggesting that USP44 overexpression repressed the activation of the Wnt/β‐catenin pathway in CRC cells. The gene discussed is CCND1; the disease is colorectal carcinoma.