The following 10 closely related genes were identified: Cdkn1a, Ccl2, Ngf, Prkar2b, Cdc42, Hif1a, Rhog, Bub3, Vegfa, and Plk4. The proteins encoded by these genes were key nodes in the PPI network and may be the main proteins associated with brain edema. The gene discussed is BUB3; the disease is brain edema.