The following 10 closely related genes were identified: Cdkn1a, Ccl2, Ngf, Prkar2b, Cdc42, Hif1a, Rhog, Bub3, Vegfa, and Plk4. The proteins encoded by these genes were key nodes in the PPI network and may be the main proteins associated with brain edema. Here, PRKAR2B is linked to brain edema.