The following 10 closely related genes were identified: Cdkn1a, Ccl2, Ngf, Prkar2b, Cdc42, Hif1a, Rhog, Bub3, Vegfa, and Plk4. The proteins encoded by these genes were key nodes in the PPI network and may be the main proteins associated with brain edema. This evidence concerns the gene CDC42 and brain edema.