AGT and respiratory failure: Astragaloside can activate the ACE2- Ang-(1-7)-Mas pathway; increase the levels of ACE2, Ang-(1-7), and Mas; and play a role in regulating lung function, thereby effectively inhibiting respiratory failure [32].The protective effect of ginsenoside Rg3 on the kidney is mainly through upregulating the expression of ACE2 in the kidney, thereby increasing the degradation of AngII, reducing the inflammation and oxidative stress mediated by AngII in the kidney, and reducing the pathological changes in the kidney [33].