Several studies have previously shown that 9-me-BC increased the gene expression of numerous neurotrophic factors like Gdnf, Bdnf, Cdnf, Cbln1, Ngf, Cntf, Gdnf receptor α and β, sonic hedgehog (Shh), wingless-type mouse mammary tumor virus (MMTV) and integration site family, member 1 and member 5a and of important transcription factors for dopaminergic neurons [engrailed homeobox 1, nuclear receptor related 1 (Nurr1) and paired-like homeodomain transcription factor 3 (Pitx3), Gata2, Gata3, Creb and Crebbp] (Polanski et al. 2010; Wernicke et al. 2010; Hamann et al. 2008). Here, EN1 is linked to breast cancer.