PTEN and cancer: In cancer cells, AT13148 blocks phosphorylation of AKT, p70S6K, PKA, ROCK, and SGK substrates and induces apoptosis; it shows in vivo anti-tumour efficacy in HER2-positive, PIK3CA-mutant BT474 breast, PTEN-deficient PC3 human prostate cancer, and PTEN-deficient MES-SA uterine human xenografts in mice (Yap et al. 2012).